Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group

C Serrarens; YJ Toenders; E Pozzi; A Aleman; N Alexander; Z Başgöze; V Belov; K Berger; K Brosch; R Bülow; GF Busatto; LP Capitão; CG Connolly; B Couvy-Duchesne; KR Cullen; U Dannlowski; CG Davey; GI de Zubicaray; D Dima; K Dohm; V Enneking; T Erwin-Grabner; U Evermann; CHY Fu; P Fuentes-Claramonte; BR Godlewska; AS Gonul; IH Gotlib; R Goya-Maldonado; HJ Grabe; NA Groenewold; D Grotegerd; O Gruber; T Hahn; G Hall; BJ Harrison; W Heindel; M Hermesdorf; TC Ho; N Ichikawa; E Itai; N Jahanshad; H Jamalabadi; AJ Jamieson; A Jansen; T Kircher; B Klimes-Dougan; B Krämer; A Krug; TM Lancaster; EJ Leehr; M Li; DEJ Linden; F MacMaster; KL McMahon; SE Medland; DMA Mehler; S Meinert; B Mwangi; I Nenadić; G Okada; Y Okamoto; N Opel; JK Pfarr; E Pomarol-Clotet; MJ Portella; R Redlich; L Reneman; J Repple; K Ringwald; E Rodriguez-Cano; PGP Rosa; MD Sacchet; PG Sämann; R Salvador; A Schrantee; H Shinzato; K Sim; E Simulionyte; JC Soares; DJ Stein; F Stein; B Straube; LT Strike; F Thomas-Odenthal; SI Thomopoulos; PM Thompson; MJ van Tol; P Usemann; A Uyar; N van der Wee; S van der Werff; Y Vives-Gilabert; H Völzke; M Walter; S Whittle; K Wittfeld; A Wroblewski; MJ Wu; TT Yang

Journal article

Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group

C Serrarens, YJ Toenders, E Pozzi, A Aleman, N Alexander, Z Başgöze, V Belov, K Berger, K Brosch, R Bülow, GF Busatto, LP Capitão, CG Connolly, B Couvy-Duchesne, KR Cullen, U Dannlowski, CG Davey, GI de Zubicaray, D Dima, K Dohm Show all

Molecular Psychiatry | Published : 2025

DOI: 10.1038/s41380-025-03310-8

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Abstract

The understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology in relation to age and sex by pooling structural neuroimaging and clinical data from 32 cohorts within the ENIGMA-MDD working group. Interaction effects of group (2076 cases with current AD use (AD), 1495 cases not currently taking AD (nAD) and 5125 healthy controls (HC)) with age and sex, and main effects of group on regional brain structure (cortical surface area and thickness, and subcortical volume) were examined. Additionally, we examined the effect of..

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